陈世敏研究员在清华大学计算机科学与技术系获得学士学位和硕士学位，在美国卡内基梅隆大学计算机科学系获得博士学位。博士毕业后，陈世敏先后在美国英特尔研究院匹兹堡研究所、卡内基梅隆大学和惠普研究院，任研究员、高级研究员和科研经理，于2013年加入中国科学院计算技术研究所计算机体系结构国家重点实验室任研究员， 并创建了数据管理系统研究组。陈世敏的研究兴趣主要集中在数据库系统、大数据处理、计算机体系结构， 获得ICDE'04最佳论文奖，SIGMOD'01亚军最佳论文奖，和2008年体系结构会议年度顶级论文奖，曾担任PVLDB 2026, ICDE 2026, PVLDB 2025, PVLDB 2017，EDBT 2024, ICDE 2018，ICDCS 2016，CIKM 2014等会议的Associate Editor/PC Area Chair/Senior PC，长期担任大数据新硬件技术的主要Workshop HardBD & Active 的Co-Chair。在中国科学院大学讲授研究生“大数据系统与大规模数据分析”课程和本科“数据库系统”课程。

数据库系统、大数据处理、计算机体系结构。

Yifan Yang, Shimin Chen. "LITS: An Optimized Learned Index for Strings". PVLDB 17(11): 3415-3427, 2024 (PVLDB'24).

Yiyuan Chen, Shimin Chen. "Cabin: a Compressed Adaptive Binned Scan Index". Proceedings of the ACM on Management of Data 2(1): 57:1-57:26 (SIGMOD'24).

Zehai Yang, Shimin Chen. "MOST: Model-Based Compression with Outlier Storage for Time Series Data". Proceedings of the ACM on Management of Data 1(4): 250:1-250:29 (SIGMOD'24).

Zhuoxuan Liu, Shimin Chen. "Pea Hash: A Performant Extendible Adaptive Hashing Index". Proceedings of the ACM on Management of Data 1(1): 108:1-108:25 (SIGMOD'23).

Jiacheng Wu, Yong Zhang, Shimin Chen, Yu Chen, Jin Wang, Chunxiao Xing. "Updatable Learned Index with Precise Positions" . PVLDB 14(8): 1276-1288, 2021 (PVLDB'21).

Gang Liu, Leying Chen, Shimin Chen. "Zen: a High-Throughput Log-Free OLTP Engine for Non-Volatile Main Memory". PVLDB, 14(5): 835 - 848, 2021 (PVLDB'21).

Jihang Liu, Shimin Chen, Lujun Wang. "LB+-Trees: Optimizing Persistent Index Performance on 3DXPoint Memory". PVLDB 13(7): 1078-1090 (PVLDB'20).

Shimin Chen, Michael Kozuch, Theodoros Strigkos, Babak Falsafi, Phillip B.  Gibbons, Todd C. Mowry, Vijaya Ramachandran, Olatunji Ruwase, Michael Ryan, Evangelos Vlachos. "Flexible Hardware Acceleration for Instruction-Grain Program Monitoring". In proceedings of the 35th International Symposium on Computer Architecture (ISCA'08) (Top Picks).

Shimin Chen, Anastasia Ailamaki, Phillip B. Gibbons, and Todd C. Mowry.  "Improving Hash Join Performance through Prefetching". In proceedings of the 20th International Conference on Data Engineering, 2004 (ICDE'04) (Best Paper Award).

Shimin Chen, Phillip B. Gibbons, and Todd C. Mowry. "Improving Index Performance through Prefetching". In proceedings of the 2001 SIGMOD International Conference on Management of Data (SIGMOD'01) (Runner-up for Best Paper Award)